IGF-1 LR3 (Long R3 Insulin-like Growth Factor)
Modified Growth Factor • 83 Amino Acids
CAS: 946870-92-4
IGF-1 LR3 is an 83-amino acid modified analog of insulin-like growth factor-1 (IGF-1) engineered with an arginine substitution at position 3 (Arg3) and a 13-amino acid N-terminal extension peptide. These structural modifications significantly reduce binding affinity to IGF-binding proteins (IGFBPs), resulting in a 2-3x increase in biological potency compared to native IGF-1. The extended half-life of 20-30 hours (versus ~12 hours for wild-type IGF-1) provides a prolonged activity window, making IGF-1 LR3 a key research tool for studying cell proliferation, intracellular signaling cascades, and muscle biology.
Key Research Findings:
- In vitro studies demonstrated 2-3x greater mitogenic potency than native IGF-1 in MCF-7 and BALB/c 3T3 cell proliferation assays
- Rodent studies showed the Arg3 substitution reduced IGFBP-3 binding by approximately 100-fold, increasing free circulating levels
- Preclinical models demonstrated significant activation of the PI3K/Akt and MAPK/ERK signaling pathways at lower concentrations than wild-type IGF-1
- In vitro muscle cell research showed enhanced myoblast differentiation and protein synthesis rates compared to unmodified IGF-1
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.